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    STUDIA PHYSICA - Ediţia nr.2 din 2011  
         
  Articol:   TETRACYCLINE LOADING AND RELEASE FROM BIOACTIVE GLASS MICROSPHERES.

Autori:  E. VANEA, S. CAVALU. 		 
       
         
  Rezumat:  Bioactive glass microspheres loaded with tetracycline for possible biomedical applications were synthesized and characterized in this work. A sol-gel derived glass matrix with the composition 45SiO2•24.5CaO•24.5Na2O•6P2O5 including 1mg/ml tetracycline was spray dried to produce microspheres. Scanning Electron Microscopy (SEM) images evidenced the spherical form of the spray dried particles. Particle size analysis showed a maximum distribution in the 8-10 µm range. The zeta potential of the microspheres dispersed in water was -12 mV at neutral pH. X-ray Photoelectron Spectroscopy (XPS) confirmed the occurrence of the antibiotic on the surface of the glass. A release study of the tetracycline loaded microspheres in simulated body fluid for 48 hours was performed using UV-Vis and fluorescence spectroscopy.

Keywords: bioactive glass; microspheres; spray drying; antibiotics release 

  
         
     
         
         
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