AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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Rezumat articol ediţie STUDIA UNIVERSITATIS BABEÅž-BOLYAI În partea de jos este prezentat rezumatul articolului selectat. Pentru revenire la cuprinsul ediţiei din care face parte acest articol, se accesează linkul din titlu. Pentru vizualizarea tuturor articolelor din arhivă la care este autor/coautor unul din autorii de mai jos, se accesează linkul din numele autorului. |
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STUDIA PHYSICA - Ediţia nr.2 din 2003 | |||||||
Articol: |
SECONDARY STRUCTURE ANALYSIS OF C-TERMINAL DOMAIN IN HUMAN CENTRIN 2 BY NMR SPECTROSCOPY AND CIRCULAR DICHROISM. Autori: ELENA MATEI, C.T. CRAESCU, P. DUCHAMBON, C. NICULESCU, Y. BLOUQUIT, S. SIMON. |
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Rezumat: Analysis of two-dimensional NMR spectra recorded from isolated C-terminal domains of human centrine 2 (HCen2) offers information on the elements of its secondary structure. Five helices (F89 - Q95, K103 –F113, F123 – E132, D139 – A149, E159 - K167) and an anti-parallel -sheet (K120-S122, E156-S158) are identified. The two EF-hand motifs form a canonical structure, similar to the “open” forms of other Ca2+-saturated regulatory domains. The structural stability and binding properties of HCen2 and its isolated domains are characterized using the circular dichroism spectroscopy. Comparative chemical stability studies reveal that the structure of the longer domain LC-HCen2 is considerably more stable than that of the shorter one SC-HCen2. | |||||||