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    STUDIA CHEMIA - Ediţia nr.2, Tom II din 2017  
         
  Articol:   KINETICS OF ZOLPIDEM AND ITS METABOLITE AFTER SINGLE DOSE ORAL ADMINISTRATION.

Autori:  ANA-MARIA GHELDIU, ALEXANDRA CSAVDARI, MARCELA ACHIM, LAURIAN VLASE, IOAN TOMUȚĂ, DANA MARIA MUNTEAN. 		 
       
         
  Rezumat:  
DOI: https://doi.org/10.24193/subbchem.2017.2.13

Published Online: 2017-06-20
Published Print: 2017-06-30

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The present study aimed to describe the basic pharmacokinetics of zolpidem and its metabolite zolpidem phenyl-4-carboxylic acid after a single oral dose of 5 mg zolpidem. Six competing kinetic models were created in order to analyze the experimental data obtained from the 20 healthy volunteers enrolled in a clinical study. Based on rational model discrimination criteria (Akaike index value), the best one was chosen and further used for a better understanding of the kinetics of zolpidem and its metabolite in the body after administration. The kinetic model considers that zolpidem absorption process follows a first-order kinetics and during this stage it is partially metabolized (pre-systemic metabolism) to its main metabolite. The kinetics of both zolpidem and its metabolite is characterized by bicompartmental distribution and first order kinetics of both elimination and systemic metabolism.

Keywords: zolpidem, zolpidem phenyl-4-carboxylic acid, compartmental pharmacokinetic analysis 		 
         
     
         
         
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