AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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Autori: RADU SILAGHI-DUMITRESCU, CRISTINA GRUIAN, CRISTINA PUSCAS, ALEXANDRA SIMON, EVA FISHER-FODOR, VLAD AL. TOMA, ANCA FARCAS, IOANA ROMAN, VIOLETA-FLORINA SCURTU, AMR A.A. ATTIA, GRIGORE DAMIAN.
DOI: 10.24193/subbchem.2020.2.10
Published Online: 2020-06-30
Published Print: 2020-06-30
pp. 121-132
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ABSTRACT: Site-directed spin labeling and EPR characterization (continuous wave as well as DEER) of two blood substitute candidates is described for the first time: glutaraldehyde-polymerized bovine hemoglobin and the related hemoglobin-albumin copolymer. In vitro, with two different types of cell cultures, these spin-labeled candidates are relatively stable; however, they appear to be rapidly reduced in vivo, most likely via removal or reduction of the spin label (as opposed to removal of the blood substitute candidate from the circulatory system altogether).
Key words: hemoglobin, albumin, blood substitute, HBOC, EPR, spin label, MTSSL, in vivo, cell culture, free radical
