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    STUDIA CHEMIA - Ediţia nr.2 din 2012  
         
  Articol:   COMPARATIVE STUDY OF DIFFERENT TLC-IMAGE ANALYSIS METHODS FOR QUANTITATIVE EVALUATION OF PARABENS IN PHARMACEUTICAL SUSPENSIONS.

Autori:  IOANA ANAMARIA TUHUŢIU, DORINA CASONI, COSTEL SÂRBU. 		 
       
         
  Rezumat:  A high-performance thin-layer chromatographic method combined with a sample preparation procedure and digital images processing has been developed for simultaneous determination of parabens in pharmaceutical suspensions. For the quantitative evaluation of the chromatographic spots, three different software that combines 2D (ImageDecipher-TLC and Sorbfil TLC) and respectively 3D (JustTLC) image analysis were investigated. The statistical parameters of the linear relation between the applied concentrations and both the peaks area and volume respectively, revealed no statistical significant differences in terms of the regression determination coefficient (R²). The lowest limits of detection and quantification values were obtained for ethylparaben and butylparaben using the ImageDecipher-TLC software. Also, by using ImageDecipher-TLC software with conversion of color images of chromatographic plates into grey scale, the precision of the developed method increased in all cases. The results obtained for commercial samples showed that the proposed method, using new UV-Vis TLC scanner device with ImageDecipher-TLC software, is suitable for rapid routine analysis of parabens in pharmaceutical suspensions.

Keywords: quantitative evaluation, parabens, HPTLC, digital processing of images, method validation 		 
         
     
         
         
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