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    STUDIA CHEMIA - Ediţia nr.1 din 2018  
         
  Articol:   THE ASSESSMENT OF FLUOROPHORES ADVANCED GLYCATION END PRODUCTS-TO-KYNURENINE RATIO IN HEALTHY AND DIABETIC RATS AND HUMANS.

Autori:  LOREDANA ELENA OLAR, DANA MIHAELA CIOBANU, FLORICA MATEI, IONEL PAPUC.
 
       
         
  Rezumat:  
DOI: 10.24193/subbchem.2018.1.03

Published Online: 2018-03-30
Published Print: 2018-03-30
pp. 37-53

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ABSTRACT:In this study, we calculated the ratio of the serum contributions of two highly studied fluorophore products (advanced glycation end products - AGEs and kynurenine - KYN) in the area of nutrition and metabolic diseases including diabetes mellitus (DM), by using a non-invasive, economical and easy-to-perform method. Blood serum spectrofluorimetric analysis was performed both in the case of normoglycemic (n=10) and diabetic rats (n=10), and in the case of non-diabetic (n=14) and type 2 diabetes mellitus (T2DM) patients (n=52). Our results showed a significant increase in the contributions of the two products in diabetic patients and rats compared to the control group. The ratio of the two compounds was positively correlated with serum glucose levels in the case of rats, and with serum triglyceride values in the case of humans. Also, the presence of DM complications in human subjects and the subsequent calculation of ROC curves led to a predictive value of the investigated ratio (AGEs/KYN) for the presence of peripheral diabetic polyneuropathy (PNP). The obtained results suggest a high potential for the investigated ratio to be considered as a new biomarker for the presence of PNP.

Keywords: Advanced glycation end products, Kynurenine, Blood serum, Diabetes Mellitus, Fluorescence Spectroscopy.
 
         
     
         
         
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