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Rezumat articol ediţie STUDIA UNIVERSITATIS BABEŞ-BOLYAI
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Rezumat:
Lung cancer is a major health concern, being the second leading cause of death after heart disease and the most common of all cancers, with 1.61 million new cases diagnosed in 2008. Radon is the primary cause of lung cancer among non-smokers and is much more likely to cause lung cancer in people who smoke. The most significant natural exposure to ionizing radiation, over 55% of all sources, comes from inhalation of radon (222Rn), thoron (220Rn) and their progeny. On the other hand, analysis of exhaled breath gains more attention in the diagnosis of pulmonary diseases and the assessment of their activity. The development of non-invasive and highly discriminating diagnostic tools is desirable in correlation with breath VOC analysis that proved to be a non-invasive test which may potentially detect lung cancer at an early stage and reduce the high mortality of the disease. The present study aims to the task of relating the leading cause of lung cancer (after smoking) with its management, including risk assessment, fraction of lung cancers attributed to radon and possible means for early diagnosis. Thus, the latest radiation biologic, experimental and epidemiologic data available in the related literature was reviewed and Ion Mobility Spectrometry (IMS) proved to be the most convenient and appropriate method for breath analysis for detecting any follow-up parameters (such as PSA in prostate cancer) that could serve as lung cancer biomarkers.
Key words: lung cancer, radon, IMS
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