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AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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Rezumat articol ediţie STUDIA UNIVERSITATIS BABEŞ-BOLYAI În partea de jos este prezentat rezumatul articolului selectat. Pentru revenire la cuprinsul ediţiei din care face parte acest articol, se accesează linkul din titlu. Pentru vizualizarea tuturor articolelor din arhivă la care este autor/coautor unul din autorii de mai jos, se accesează linkul din numele autorului. |
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STUDIA CHEMIA - Ediţia nr.3 din 2021 | |||||||
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BIOMIMETIC NANOCOMPOSITE STRUCTURES DESIGNED FOR COATING OF ORTHOPEDIC IMPLANTS: AFM INVESTIGATION. Autori: REKA BALINT, IOAN PETEAN, PETRE T. FRANGOPOL, AURORA MOCANU, GEORGE ARGHIR, SORIN RIGA, GHEORGHE TOMOAIA, OSSI HOROVITZ, MARIA TOMOAIA-COTISEL. |
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Rezumat: DOI: 10.24193/subbchem.2021.3.08 Published Online: 2021-09-30 Published Print: 2021-09-30 pp. 141-160 VIEW PDF FULL PDF Titanium implants are highly resistant to external forces and have affordable prices but the contact between Ti metal and surrounding native tissue could provoke an immunological response. The developing of biomimetic coating onto the Ti surface proves to be a smart choice to enhance the osseointegration and ensure an optimal healing process, due to the creation of nanostructured biomaterials like those in native bone. Thus, we designed a composite coating based on multi-substituted hydroxyapatite (noted ms-HAP or HAPc) nanoparticles, NPs, doped with essential elements: Mg, Zn and Si, functionalized with collagen type 1 (COL), embedded into poly lactic acid, PLA, matrix, and finally covered with COL layer to achieve biomimetic structures. Thin layers of biomimetic composite were self-assembled onto Ti surface via dip-coating method. Both, initial and coated Ti implants were investigated by atomic force microscopy (AFM), which allows surface investigation at high resolution of nano-level. COL amount in composite might self-assemble as COL fibers assuring a biomimetic structure, characterized by important features, like suitable porosity to facilitate the delivery of nutrients to osteoblasts and proper nano-topography and surface roughness to promote cell adhesion and proliferation. The outermost layer is of pure collagen which could assure a natural attachment to the bone tissue promoting osseo-integration. Keywords: biomimetic structure, bio-composite, multi-substituted hydroxyapatite, collagen, PLA, AFM images, surface roughness |
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