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AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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STUDIA BIOLOGIA - Ediţia nr.2 din 2011 | |||||||
Articol: |
EVALUATION OF THE INHIBITORY EFFECTS OF STATINS ON BLOOD VESSEL DEVELOPMENT – PROSPECTS FOR ANTIANGIOGENIC THERAPY OF CANCER. Autori: RAMONA MARIA MAXIM, MARIUS COSTEL ALUPEI, SEPTIMIU TRIPON, MANUELA BANCIU. |
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Rezumat: Statins have a primary activity related to cholesterol lowering in cardiovascular diseases. Besides their main pharmacological action, statins have pleiotropic activities with possible harmful effects on processes associated with tumor development: angiogenesis, inflammation, and metastasis. The present work has shown the effects of statins on formation of blood vessels in a chicken chorioallantoic membrane (CAM) model in vivo. Statins have been selected based on their potency to reduce cholesterol levels in blood in the following order simvastatin> lovastatin> pravastatin. The inhibitory effects of statins on vasculature development might be a promise for their future application in anticancer antiangiogenic therapy. Keywords: angiogenesis, CAM assay, statins |
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