![]()
AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
|
|||||||
Rezumat articol ediţie STUDIA UNIVERSITATIS BABEŞ-BOLYAI În partea de jos este prezentat rezumatul articolului selectat. Pentru revenire la cuprinsul ediţiei din care face parte acest articol, se accesează linkul din titlu. Pentru vizualizarea tuturor articolelor din arhivă la care este autor/coautor unul din autorii de mai jos, se accesează linkul din numele autorului. |
|||||||
STUDIA CHEMIA - Ediţia nr.2 din 2009 | |||||||
Articol: |
HIGH-THROUGHPUT DETERMINATION OF IVABRADINE FROM HUMAN PLASMA BY LC/MS/MS AND ITS APPLICATION TO PHARMACOKINETIC STUDIES. Autori: LAURIAN VLASE, DANA MUNTEAN, SORIN E. LEUCUŢA, IOAN BÂLDEA. |
||||||
Rezumat: A rapid, selective, sensitive and reproducible liquid chromatographic method with mass spectrometric detection (LC-MS/MS) has been developed and validated for the analysis of a bradycardic agent, ivabradine, in human plasma. The samples (0.2 ml) were precipitated using perchloric acid 7% (0.1 ml) and the centrifuged supernatants were injected into HPLC system. Separation and detection of ivabradine were achieved using a C18 column and an MS/MS detector, with a positive electrospray ionization source. The ion transition monitored was 469→(177 262). Ivabradine gave a linear response ranging from 0.49 ng/ml to 49.30 ng/ml. The lower limit of quantification was established at 0.49 ng/ml. The analyte demonstrated good short-term, post-preparative and freeze-thaw stability. The validated method was subsequently applied to a pharmacokinetic study of ivabradine tablets on healthy volunteers. Keywords: ivabradine, pharmacokinetics, LC-MS/MS, human plasma |
|||||||
![]() |
|||||||