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    STUDIA PHYSICA - Issue no. 2 / 2010  
         
  Article:   ANTI-TUMORAL BETULIN DETECTION BY SURFACE ENHANCED RAMAN SCATTERING.

Authors:  N. LEOPOLD, C. LEHENE, VASILE CHIŞ, SIMONA CINTĂ PÂNZARU. 		 
       
         
  Abstract:  Betulin, a lupan skeleton compound isolated from the outer bark of the birch tree has been recently topical formulated as antitumor compound effective in melanoma treatment. Aiming to monitor the pharmaceutical damaged skin therapy using SERS, we report here new results on betulin adsorption availability using surface enhanced Raman scattering (SERS). The SERS spectra of betulin dissolved in DMSO aqueous solution have been recorded and discussed in order to further detect the active compound in several new semisolid pharmaceutical formulations. On the basis of our earlier spectroscopic results in conjunction with DFT calculation, SERS spectra have been completely assigned and compared to those of betulinic acid previously reported. A chemisorption process was concluded, based on the dramatic change in the bands position and relative intensity. The CH2OH functional group was found to be involved in adsorption.

Key words: betulin, SERS, Raman, pentacyclic triterpene. 

 
         
     
         
         
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