AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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The STUDIA UNIVERSITATIS BABEŞ-BOLYAI issue article summary The summary of the selected article appears at the bottom of the page. In order to get back to the contents of the issue this article belongs to you have to access the link from the title. In order to see all the articles of the archive which have as author/co-author one of the authors mentioned below, you have to access the link from the author's name. |
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STUDIA PHYSICA - Issue no. 2 / 2010 | |||||||
Article: |
ANTI-TUMORAL BETULIN DETECTION BY SURFACE ENHANCED RAMAN SCATTERING. Authors: N. LEOPOLD, C. LEHENE, VASILE CHIŞ, SIMONA CINTĂ PÂNZARU. |
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Abstract: Betulin, a lupan skeleton compound isolated from the outer bark of the birch tree has been recently topical formulated as antitumor compound effective in melanoma treatment. Aiming to monitor the pharmaceutical damaged skin therapy using SERS, we report here new results on betulin adsorption availability using surface enhanced Raman scattering (SERS). The SERS spectra of betulin dissolved in DMSO aqueous solution have been recorded and discussed in order to further detect the active compound in several new semisolid pharmaceutical formulations. On the basis of our earlier spectroscopic results in conjunction with DFT calculation, SERS spectra have been completely assigned and compared to those of betulinic acid previously reported. A chemisorption process was concluded, based on the dramatic change in the bands position and relative intensity. The CH2OH functional group was found to be involved in adsorption. Key words: betulin, SERS, Raman, pentacyclic triterpene. |
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