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    STUDIA PHYSICA - Issue no. 2 / 2008  
         
  Article:   STATISTICS FOR CIRRHOSIS DIAGNOSIS BY GC/MS.

Authors:  ANDREEA IORDACHE, CORNELIA MESAROS, MONICA CULEA, ONUC COZAR.
 
       
         
  Abstract:  Gas chromatographic-mass spectrometry (GC/MS) is one of the best methods used for measuring drugs in biological fluids. The selected ion monitoring (SIM) mode was used in caffeine test measurements by adding known amounts of 15N-theophylline as internal standard. A single dose of 4 mg.kg-1 p.o. of caffeine was followed by blood concentrations measurements at two points, 1h and 9 h. Caffeine clearance, measured in patients with cirrhosis and chronic hepatitis, was reduced and half live time was increased in children with liver disease as compared with control. Different statistical methods have been used to study the pharmacokinetic data for cirrhosis diagnosis.

Keywords: Gas chromatographic-mass spectrometry, statistical methods, diagnosis.
 
         
     
         
         
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