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    STUDIA PHYSICA - Issue no. 2 / 2002  
         
  Article:   INVESTIGATION OF IRRADIATED DRUG INGREDIENTS BY ESR SPECTROSCOPY.

Authors:  GHEORGHE DAMIAN.
 
       
         
  Abstract:  The active drug ingredients (amino acids) and inactive drug ingredient (starch), have been investigated by ESR spectroscopy in order to detect stable paramagnetic species following sterilization by gamma radiation. The absorbed dose of drugs was 25 kGy corresponding to the dose used in the sterilization process. ESR measurements proved that studied active ingredients contains various stable paramagnetic species after irradiation. The irradiated samples show large signals, more or less complex, depending on the chemical nature of the amino-acid. Some spectroscopic properties and suggestions concerning possible structure of the radicals are discussed in this paper.  
         
     
         
         
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