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    STUDIA PHYSICA - Issue no. 1-2 / 2017  
         
  Article:   XRD CHECKING OF CRYSTALLINE FORMS RESULTED BY SLOW EVAPORATION OF 5-FLUOROURACIL SOLUTIONS OBTAINED WITH DIFFERENT SOLVENTS.

Authors:  C. MOISESCU-GOIA, M. MURESAN-POP, V. SIMON.
 
       
         
  Abstract:  
The present study aimed to obtain new crystalline forms of 5-fluorouracil (5-FU) chemotherapy drug after 5-FU solvation in different solvents, considering the crystallization by slow evaporation. The expectation was to obtain 5-FU polymorphs. 5-FU was tested in aqueous solutions of 14 solvents. After slow evaporation of solutions (11) or suspensions (3), the obtained crystalline forms were examined by checking their X-ray diffraction patterns. Only for acetonitrile solution resulted a polymorph of 5-FU.

Key words: 5-fluorouracil; solubility; X-ray diffraction; polymorphs.
 
         
     
         
         
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