AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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Authors: SÎRBU ELENA, GLIGOR ȘERBAN.
DOI: 10.24193/subbeag.63(4).31
Published Online: 2018-12-20
Published Print: 2018-12-20
pp. 29-39
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Background: Cholesterol-lowering therapy (statins), associated with lifestyle modifications, have an important role in reducing atherosclerotic cardiovascular disease (ASCVD) events. Methods: We review the literature to explore the mechanisms of myopathy caused by statins and also to examine the effects of combining statin therapy with physical activity. Results: Although statins are usually well tolerated, dose dependent side effects including myopathy and others side effects were reported. Mechanism of myopathy caused by statins is unclear, but there are some theories to explain these. A large number of evidence suggests the protective effect of regular exercise against chronic diseases and this may be mediated trough their anti-inflammatory effect. There are a number of factors (age, genetic factors, vitamin D) influencing the interaction between statins, skeletal muscle and exercise. It is difficult to associate statin therapy with increased aerobic fitness, because of local adverse effects (muscular or hepatic), which tend to decrease patients’ physical activity levels. Conclusion: Caution should be taken to the combination of the statin therapy with physical activity, especially in people with increased risk of local effects.
Keywords: exercise training, statins, musculoskeletal, cardiovascular
