AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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Introduction. Pro oxidant effect of intense physical effort, its consequences and the importance of combating nitrosative stress is a topical issue of interest, according to the literature. Combating this effect is achieved by administration of exogenous nutritional or non nutritional, natural or synthetic antioxidants. The influence of nutrition, the antioxidant and pro oxidant effect of moderate exercise is added to this aspect. Hemp seed oil is a natural source of antioxidants whose beneficial effects on the balance of serum oxidant / antioxidant in exercise rats was the subject of our previous research. Objectives. We aim to study the effect of the administration of hemp oil on indicators of tissue oxidant/antioxidant balance in the myocardium and brain in the exercise training with gradual intensity. Methods. The research was conducted on two groups of male, adult Wistar rats. Group I consisted of rats trained at progressive intensity exercise, group II consisted of rats trained with progressive intensity exercise and supplemented with hemp oil. Indicators of oxidative stress: malondialdehyde (MDA), protein carbonyls (PC) were determined. Antioxidant defense capacity indicators were hydrogen donor (DH), total sulfhydryl groups (SH), glutathione (GSH). For statistical analysis, data for normal distribution we used the t (Student) and one-way ANOVA analysis of variance. Results. The intensity progressive exercise and dietary supplementation with hemp oil produce significant changes in the myocardium and brain with increased indicators of oxidative stress and increased antioxidant defense versus unsupplemented group. Conclusions. Hemp oil supplementation and progressive intensity exercise affect the oxidant/antioxidant balance in the tissues, causes significant increases in oxidative stress and increases antioxidant defense in brain and myocardium.
Keywords: oxidative stress, nutritional antioxidants, myocardium, brain
