AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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Background: The antioxidant effects of lycopene, evidenced in vitro and in vivo under pathological conditions, made us study in an experimental model of complex combined stress (exposure to moderate hypobaric hypoxia, ozone and physical exercise) the acute changes in the tissue oxidant/antioxidant (O/AO) balance following lycopene supplementation. Aims: The influence of acute hypobaric hypoxia, ozone exposure and lycopene supplementation on tissue redox homeostasis under physical exercise conditions was studied in the brain. Material and methods: The researches were performed in 6 groups of white male Wistar rats: group I – control group, sedentary rats under normoxia conditions; group II – sedentary rats exposed to acute combined stress: hypobaric hypoxia (corresponding to a 2500 m altitude) and acute O3; group III- animals exposed to acute combined stress - moderate hypoxia + acute O3 -, followed by exercise, under normoxia conditions; group IV - sedentary rats under normoxia conditions, with lycopene administration; group V - animals exposed to acute combined stress - moderate hypoxia + acute O3 -, followed by lycopene administration; group VI - animals exposed to acute combined stress - moderate hypoxia + acute O3 -, followed by lycopene administration and daily exercise, under normoxia conditions. Exposure was simulated in the hypobaric chamber for 3 days, 20 hours a day, at 2500 m. Groups III and VI were trained daily for 3 days under normoxia conditions, by the swimming test. Groups IV, V and VI received 0.0375 mg/kg body weight lycopene by oral gavage, (before exercise by group VI), daily. In order to measure the indicators of the oxidant/antioxidant (O/AO) balance, tissue samples were taken from the brain. On day 3, the following were determined: malondialdehyde (MDA), protein carbonyls (PC), hydrogen donor capacity (HD) and total sulfhydryl (SH) groups. Results: Our experimental results obtained in animals that were exercise trained for 3 days and subjected to combined acute stress – hypobaric hypoxia and O3 – and lycopene administration, support the favorable effects of lycopene as an antioxidant on the brain under rest conditions. Conclusions: Lycopene administration in animals subjected to combined acute stress – hypobaric hypoxia and O3, followed by exercise – determines an increase in AO defense on account of HD in the brain, and a decrease in AO defense on account of SH in the brain, compared to control animals.
Keywords: acute exposure, hypobaric hypoxia, ozone, lycopene, oxidant/ antioxidant balance, physical exercise, brain.
