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    STUDIA CHEMIA - Issue no. 4, Tom I / 2017  
         
  Article:   PERIODATE-OXIDIZED ALGINATE AS POLYCONDENSATION REAGENT FOR HEMOGLOBIN.

Authors:  FLORINA SCURTU, ANAMARIA POPA, RADU SILAGHI-DUMITRESCU. 		 
       
         
  Abstract:  We have previously demonstrated that derivatization of hemoglobin with periodate-modified sugar derivatives incurs increases in the pro-oxidant reactivity and, also, that serum bovine serum albumin can resolve this problem entirely. Here, we described a new polymer based on hemoglobin and another oxygen-containing compound, alginate. The rate of autooxidation increases after derivatization, but serum albumin alleviates this problem. The peroxide reactivity and oxygen affinity were also tested but no significant differences were observed between derivatized and native hemoglobin.

Keywords: blood substitute, hemoglobin, alginate, oxidative stress 		 
         
     
         
         
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