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    STUDIA CHEMIA - Issue no. 4 / 2010  
         
  Article:   CISPLATIN EFFECT ON HEMOGLOBIN AND MYOGLOBIN AUTOOXIDATION.

Authors:  CRISTINA BISCHIN, VICENTIU TACIUC, RADU SILAGHI-DUMITRESCU.
 
       
         
  Abstract:  

It has previously been shown using mass-spectrometry that therapeutically-useful platinum-based compounds of the cisplatin family bind to a range of proteins, including hemoglobin and cytochrome c. On the other hand, currently available data suggests that the medically-relevant chemical properties of hemoglobin are in no significant way affected by Pt-based drugs, within the concentration ranges attainable during treatment of a patient. Here, cisplatin is shown to modulate two physiological parameters of hemoglobin and myoglobin - autooxidation and oxygen dissociation rate, as measured by UV-vis aspectra. The extent, to which these changes in reactivity impact the side-effects and even the therapeutic mechanisms of these drugs, appears to deserve further attention.

Keywords: hemoglobin, cytochrome c, cisplatin, autooxidation

 
         
     
         
         
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