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    STUDIA CHEMIA - Issue no. 2, Tom II / 2019  
         
  Article:   A PREDICTIVE TOXICITY STUDY OF PEIs, PAMAM AND ZAC DENDRIMERS.

Authors:  CLAUDIU N. LUNGU, CSABA PAIZS, MELINDA E. FÜSTÖS, ANAMARIA ORZA, MIRCEA V. DIUDEA, IRENEUSZ P. GRUDZINSKI. 		 
       
         
  Abstract:  Polyethyleneimines (PEIs) and polyamidoamine dendrimers (PAMAM) are widely used as non-biological transporters in modern gene therapies. In this study, several zero-generation aromatic core ZAC dendrimers were computationally studied for predictive toxicity assessment. The chemical synthesis of the ZAC dendrimers was carried out using three different bromomethylbenzene derivatives as aromatic core and dialkanolamines as branching units with different carbon chain length. Quantitative structure-activity relationships (QSAR) and virtual high throughput toxicity screening (vHTTS) assays were applied on the synthesized zero generation dendrimers to evaluate their toxicities.

Keywords: molecular descriptors, pharmacophore, QSAR, continuous structures, toxicity, maximum recommended daily dose, dendrimers. 		 
         
     
         
         
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