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Authors: ADRIANA GROZAV, BOGDAN STANCU, COSMINA BOARI, FLORE CHIRILA, NICODIM FIT, CASTELIA CRISTEA.
DOI: https://doi.org/10.24193/subbchem.2017.2.29
Published Online: 2017-06-20
Published Print: 2017-06-30
VIEW PDF: Nˊ-BENZYLIDENE-N-(THIAZOLYL)ACETOHYDRAZIDE DERIVATIVES …
A series of new Nˊ-benzylidene-N-(thiazolyl)acetohydrazide derivatives was obtained by the acetylation of 2-(2-benzylidenehydrazinyl)thiazole derivatives using acetic anhydride. The antimicrobial activity of the new and parent compounds was screened against Gram-positive and Gram-negative bacteria using agar well diffusion method. 4-Methyl-2-[2-(4-hidroxibenzylidene)-hydrazinyl)-thiazole was identified as the most efficient, with a broad activity spectrum against both Gram positive and Gram negative bacteria.
Keywords: acetohydrazide, thiazole, antimicrobial
