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    STUDIA CHEMIA - Issue no. 2 / 2006  
         
  Article:   INHIBITORY EFFECT OF METOPROLOL UPON CATALASE–H2O2 DECOMPOSITION, USED AS A POTENTIAL KINETIC METHOD TO DETERMINE THE DRUG CONCENTRATION.

Authors:  FLORINA POGACEAN, I. BALDEA, FLORIN TURBAT. 		 
       
         
  Abstract:  The enzyme catalyzed process of decomposition of hydrogen peroxide has been investigated by means of a Clark oxygen sensor, in the presence and absence of various concentrations of Metoprolol – a -blocker drug - having an inhibiting role. The Michaelis – Menten kinetic parameters of H2O2-catalase reaction have been determined from Lineweaver-Burk plots. The inhibition pattern we have deduced, suggested by the Lineweaver - Burk plots, corresponds to a fully mixed inhibition mechanism. Inhibition constants KI and KI’ were determined. The inhibitory effect can be used to determine metoprolol in low concentrations by a kinetic method.  
         
     
         
         
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