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    STUDIA CHEMIA - Issue no. 1 / 2009  
         
  Article:   PROCAINE EFFECTS ON SURFACE TOPOGRAPHY OF SPREAD DIPALMITOYL PHOSPHATIDYLCHOLINE MONOLAYERS.

Authors:  PETRE T. FRANGOPOL, D. ALLAN CADENHEAD, MARIA TOMOAIA-COTIŞEL, AURORA MOCANU. 		 
       
         
  Abstract:   The surface topography of dipalmitoyl phosphatidylcholine (DPPC) monolayers, spread at the air/water interface, in the absence and the presence of procaine, has been investigated by self-assembly Langmuir-Blodgett (LB) technique and atomic force microscopy (AFM), operating in tapping mode. The LB monolayers were transferred on mica, at a controlled surface pressure, characteristic for the liquid expanded to liquid condensed phase transition of pure DPPC monolayers. Our data indicate that procaine penetrates into and specifically interacts with DPPC monolayers stabilizing the phospholipid membrane interface.

Keywords: DPPC, procaine, monolayers, AFM, LBT, phase transition 		 
         
     
         
         
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