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    STUDIA BIOLOGIA - Issue no. 2 / 2007  
         
  Article:   REVIEW=== IRON METABOLISM DISORDER EXPLORATION: CLASSICAL AND MODERN PARAMETERS.

Authors:  MARIANA PATIU, GABRIEL LASZLO. 		 
       
         
  Abstract:  The biochemical serum markers commonly used to investigate iron metabolism proved to be effective means in solving many of the diagnostic problems raised by the various clinical settings encountered in practice. However, other investigations – hematological ones, assessing the hemoglobinization of red cells – are needed for real-time differentiation between anemia of chronic disease with and without functional iron deficiency. Combining the biochemical and hematological parameters into a single diagram (the so-called diagnostic&therapeutic plot) provides yet another valuable diagnostic tool, useful also in therapy. The recently discovered liver hormone hepcidin appears to be the central regulator of iron metabolism. Other proteins, as well as certain genes, involved in iron metabolism have also been discovered lately, some of them with diagnostic or therapeutic potential.  
         
     
         
         
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