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    STUDIA BIOLOGIA - Issue no. 2 / 2006  
         
  Article:   CIRCULATORY DITURBANCES INDUCED BY SOME ALKYLATING AGENTS WITH PLATINUM IN WHITE WISTAR RATS.

Authors:  CRISTINA PAŞCA, VICTORIA-DOINA SANDU.
 
       
         
  Abstract:  The alterations induced by Cisplatin and Carboplatin (administered in equivalent doses and in monochemotherapy) at the level of the kidney, thymus, heart, liver, pancreas, digestive tract and lungs seem to be due (induced, maintained and then aggravated owing) to the grave circulatory disturbances such as: blood stasis, congestion, oedemas, haemorrhages and disseminate intravascular coagulation phenomena. All these circulatory alterations could be due both to the direct toxic effect of the drugs and thrombocytopenia induced by the two alkylating agents. Finally, they determine at the level of the organs a serious deficient supply with oxygen and nutritive substances, and, simultaneously, an accumulation of some toxic metabolic products which explain the massive destructions of the cells of parenchyma. The intensity, gravity and extension of the circulatory modifications were different, depending on the type of drug, organ and the moment of the sacrification. Thus, Carboplatin seems to possess a higher and longer toxic activity compared to Cisplatin, which appears immediately, aggravates progressively and significantly. In addition, circulatory disturbances induced by Carboplatin were graver, and affected especially the myocardium, thymus, pancreas and digestive tract. Cisplatin had a stronger toxic action on the vessels in the kidneys and lungs. Only moderate alterations of the circulatory system in the liver were induced by these drugs. Both cytostatics generated many vascular (and cellular) alterations with no irreversible character, so that, at the end of the experimental period, without any protective or regenerative treatment, an obvious recovery process could be observed at the level of the most affected organs.  
         
     
         
         
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