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    STUDIA BIOLOGIA - Issue no. 2 / 2005  
         
  Article:   PREVENTION OF SPONTANEOUS AUTOIMMUNE DIABETES IN NON OBESE DIABETIC MICE BY RAPAMYCIN AND RAPAMYCIN-IL-10 COMBINATION.

Authors:  CAMELIA LANG, ELENA DRĂGHICI, CORNELIU TARBA.
 
       
         
  Abstract:  Rapamycin is an immunosuppressive drug that prevents rejection of pancreatic islet allografts transplanted into patients with Type 1 (insulin-dependent) diabetes mellitus. This study aimed to determine if rapamycin and/or rapamycin- IL-10 combination can indeed prevent diabetes incidence or only produce a delay in onset of diabetes. Rapamycin alone and rapamycin-IL-10 combination were given separately and together to female non-obese diabetic (NOD) mice for 15 weeks beginning with 11 weeks of age. Diabetes incidence was determined and plasma glucose and insulin concentrations were measured. Rapamycin prevented diabetes in female NOD mice (9.09% incidence in rapamycin and rapamycin-IL-10 treated mice vs. 66.66% in vehicle-treated mice). However, although we showed an improvement of plasma glucose and insulin concentrations after rapamycin administration, these changes were due to an improvement in insulin sensitivity and not to an improvement in beta-cell function. These findings suggest that rapamycin and rapamycin-IL-10 combination only delay diabetes onset.  
         
     
         
         
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