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    STUDIA BIOLOGIA - Issue no. 2 / 2003  
         
  Article:   MODIFICĂRI STRUCTURALE ŞI ULTRASTRUCTURALE INDUSE DE NUROFEN LA NIVELUL COMPONENTELOR MUCOASEI GASTRICE LA ŞOBOLANUL ALB WISTAR.

Authors:  CRISTINA PAŞCA, CONSTANTIN CRĂCIUN, VICTORIA-DOINA SANDU.
 
       
         
  Abstract:  Structural and Ultrastructural Modifications Induced by Nurofen at the Level of the Components of Gastric Mucosa in White Wistar Rats. According to the light and electron microscopy investigations carried out by us, the dose of 250 mg Nurofen/kg body weight, administered for 35 days, has a significant toxic effect on the whole gastric mucosa of the white Wistar rats, but especially upon the body and fundic region of the stomach. Obvious modifications induced by this nonsteroidial anti- inflammatory drug could be noticed, even after 10 days of treatment, and got worse progressively and continuously until the end of the experimental period. Nurofen, a drug widely used by people in the whole world, disturbed significantly both the vascular and cellular components in the gastric mucosa, especially the mucous surface cells and the gastric gland epithelium (chief cells, parietal cells, endocrine cells, mucous neck cells and auxiliary cells). The lamina propria and muscularis mucosae were discretely affected by the treatment with Nurofen. Ultrastructurally, the alteration of the chief cells affected principally their nuclei, which appeared pycnotic, retracted, hyperchromatic, with a peculiar disposition of the chromatin and with a swollen nuclear envelope. The oedema affected the rough-surfaced endoplasmic reticulum and mitochondria of these cells, too. As a direct consequence of all structural changes described above, there was a significant decrease of the pepsinogen secretory activity. At the level of parietal cells we could observe the appearance of some intracytoplasmic lysis phenomena, correlated with a progressive necrosis process. The most sensitive organelles seemed to be the mitochondria, which appeared swollen and greatly alterated, having the matrix and cristae seriously affected. Besides, the secretion of HCl by these cells decreased significantly. Among the endocrine cells of the gastric mucosa, only a few types of them seemed to be affected by Nurofen. These cells presented an obvious vacuolised cytoplasm, pycnotic nuclei, swollen mitochondria, and just a small number of secretion drops. Possibly, the cells altered by this drug were those responsible for the synthesis of serotonine. That could justify the serious alteration of the vascular component in stomachal mucosa and submucosa (vascular congestion, blood stasis and numerous microhaemorrhages), which could induce and maintain the necrosis processes. Both the auxiliary and mucous neck cells in gastric mucosa seemed to be resistant to the treatment with this antiinflammatory medicine. Fortunately, our investigations demonstrated that the neighbouring gastric glands had a polymorphous histological and ultrastructural aspect, demonstrating that Nurofen had no identical effect on their structure and function. In addition, generally, the alterations induced by this drug had no irreversible character, a recovery process of the gastric mucosa after the end of the treatment being thus possible.  
         
     
         
         
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