AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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Authors: VALERIA CRISTINA BULGARU, GINA CECILIA PISTOL, DANIELA ELIZA MARIN, IONELIA TARANU.
Published Online: 2021-06-30
Published Print: 2021-06-30
pp. 11-12
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ABSTRACT: Zearalenone (ZEA) is a mycotoxin produced by fungi of the genus Fusarium, that frequently contaminate wheat, barley and rye crops and affects both human and animal health. Swine is one of the most susceptible species to ZEA intoxication, this fact being due to the high intake of cereals in the diet, but also to a high sensitivity to mycotoxins. The aim of this study was to investigate the effects produced by exposure of weaned piglets to a low dose of ZEA. Some immune parameters as immunoglobulins (IgG, IgA, IgM), nitric oxyde (NO) and also biochemical parameters related to energetic (glucose, cholesterol, triglyceride), proteic (total protein, albumin, ureea, creatinine), mineral (Ca, Fe, Mg, P) profile as well as the activity of some hepatic enzymes (aspartat amino-transferase, alanil-amino-transferase, gamma-glutamil transferase and alcaline phosphatase) were assesed in piglets serum. The in vivo experiment was performed on 12 crossbred weaned piglets (TOPIGS-40), randomly assigned to two groups (6 animals/group): control group (C) fed uncontaminated feed and experimental group (E) fed a ZEA contaminated diet (75µg/kg feed) for 21 days. The main immunological change induced by ZEA was the decrease in IgG (P=0.0428) and NO concentration (P=0.0176). The exposure to ZEA significatly decreased the bilirubin concentration (P=0.0077) and tended to decrease the serum glycemia (P=0.07). By contrast ZEA increased the triglycerides concentration (P=0.0004) and gammaGT activity (P=0.0003). In conclusion, ZEA can affect immunological and biochemical parameters in weaned piglets, even in concentrations lower than recommended by European Comission for swine feed.
Key words: biochemistry, immunology, swine, zearalenone
