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    STUDIA BIOLOGIA - Issue no. 1 / 2005  
         
  Article:   MODIFICĂRI ULTRASTRUCTURALE ŞI BIOCHIMICE INDUSE DE TRATAMENTUL CU DERMOVATE LA ŞOBOLANI PREPUBERI.

Authors:  ERIKA KIS, CONSTANTIN CRĂCIUN.
 
       
         
  Abstract:  Ultrastrucutral and Biochemical Alterations Induced by Dermovate Treatment in Prepubertal Rats. It is well known that glucocorticoid therapy includes a variety of useful applications related to the multiple effects of this class of compounds. These include antiinflamatory, antiallergic, immunosuppressor or antitumor activities. Due to the ubiquitous nature of the glucocorticoid receptors and the intrinsic multiple activity of glucocorticoids there are a number of unwanted side effects. Most of these are receptor-mediated and are typical corticosteroid effects, such as suppression of pituitary-adrenal axis. Other side effects, including growth inhibition in children or skin thinning during topical application, in addition to systemic side effects, could present serious problems. In recent studies elsewere we have reported that the short-term epicutaneouse application of some halogenated or unhalogenated topical glucocorticosteroids in young rats, exert steroid-diabetogen secondary side-effects, manifested throught hypergliycemia, hepatic glucose overproduction, elevated serum lipids and muscular resistance to insulin. All these endocrine-metabolic disorders were accompanied by thymolisis, adrenal atrophy and several ultrastructural modifications in some pituitary and adrenal cells. Starting from the above obervations and from the important physiological roles of the pituitary-adrenal axis in young organisms, we investigated ultrastructural modifications and some metabolic reactions in prepubertal rats after a short-term epicutaneous treatment with Clobetasol-propionate containing cream.  
         
     
         
         
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