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    STUDIA BIOLOGIA - Issue no. 1 / 2001  
         
  Article:   COMPARATIVE STUDIES OF THE ADRENAL CORTEX STRUCTURE AND ULTRASTRUCTURE IN MATURE RATS TREATED WITH TOPICAL DERMOCORTICOSTEROIDS.

Authors:  CONSTANTIN CRĂCIUN, ERIKA KIS, VICTORIA-DOINA SANDU, CRISTINA PAŞCA, CONSTANTIN PUICĂ, VERONICA CRĂCIUN, IOSIF MADAR. 		 
       
         
  Abstract:  It is well established that synthetic topical corticosteroids, widely applied in human dermatology, exert, beside their excellent local action, adverse secondary systemic side effects, due to their epicutaneous absorption capacity. There are still very few correlative research works about the influence of glucocorticoids at systemic level, especially about those used in very common drugs, widely recommended to patients, such as Locoid, Dermovate and Fluocinolone-N, which were studied in our works. In order to obtain complete data about the action of these glucocorticoids upon some endocrine glands (thymus, adrenals, pituitary gland) especially of young animals, our research work was done primarily on prepubertal and pubertal rats. Our results indicate that Locoid has moderate potent actions, with reversible modifications, while Dermovate has potent effects and Fluocinolone-N superpotent effects, inducing the most severe modifications. Therefore, it is recommended that the topical use of this steroid class for long-term therapy be limited or to find possibilities for improving the benefit/risk ratio between their local and systemic adverse side actions.  
         
     
         
         
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