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    STUDIA AMBIENTUM - Issue no. 1-2 / 2008  
         
  Article:   THE IMPORTANCE OF SOME NON-TARGETTED CELLULAR EFFECTS IN ASSESSING THE LUNG CANCER RISK INDUCED BY RADON AND ITS PROGENY.

Authors:  LUCIA-ADINA TRUŢĂ-POPA, WERNER HOFMANN, CONSTANTIN COSMA. 		 
       
         
  Abstract:  Until about two decades ago, there was a dogma in radiation sciences that biological effects appear only in case of direct irradiation of cells, when energy deposition occurs in the nucleus of the cell. Lately, a different approach than the deterministic relationship “hit-effect” model was adopted in radiobiology, in favor of some concepts regarding the responses at the cellular level. At low doses of exposure to ionizing radiation a number of delayed, non-targeted effects of cells not directly hit by radiation were reported. In this study, a mechanistic model was proposed, for estimating the lung cancer risk induced by direct and particularly indirect biological cellular effects that occurred after exposure to alpha particles. The objective of the present study was to explore the role of non-targeted cellular radiation effects on the shape of the dose-effect curve in the low dose region, i.e. to investigate whether mechanisms such as bystander effects and adaptive response will increase or decrease lung cancer risk shape at radon exposure levels characteristic of residential exposures.

Keywords: non-targeted effects, lung cancer, risk, bystander, adaptive response 		 
         
     
         
         
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