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AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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The STUDIA UNIVERSITATIS BABEŞ-BOLYAI issue article summary The summary of the selected article appears at the bottom of the page. In order to get back to the contents of the issue this article belongs to you have to access the link from the title. In order to see all the articles of the archive which have as author/co-author one of the authors mentioned below, you have to access the link from the author's name. |
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STUDIA BIOLOGIA - Issue no. 1 / 2023 | |||||||
Article: |
DIFFERENTIAL EXPRESSION OF hsa_circ_0064357 AND hsa_circ_0064358 BETWEEN ORAL SQUAMOUS CELL CARCINOMA AND ORAL LICHEN PLANUS. Authors: ROXANA NADERI, FARANAK JAMSHIDIAN. |
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Abstract: DOI: 10.24193/subbbiol.2023.1.04 Article history: Received: 28 January 2023; Revised: 5 April 2023; Accepted: 25 May 2023; Available online: 30 June 2023. ©2023 Studia UBB Biologia. Published by Babeş-Bolyai University. pp. 51-65 VIEW PDF FULL PDF Background/aims: Reliable biomarkers with high specificity and sensitivity and the potential to discriminate precancerous or early lesions from oral cancer improve scientific assessment and early detection. Dysregulated circRNAs play a critical role in the occurrence and progression of malignant biological behaviors of OSCC. The study of potential diagnostic roles of hsa_circ_0064357 and hsa_circ_0064358 in early diagnostic of precancerous lesions such as OLP to OSCC as the most common type of head-and-neck squamous cell carcinoma (HNSCC) was the focus of present research. Methods: The differential expression of hsa_circ_0064357, hsa_circ_0064358, and RAF1 target gene predicted using CircInteractome and Circbase databases between OSCC (n=30), OLP (n=10) tissues and their adjacent normal tissues were evaluated by qRT-PCR. The potential diagnostic value of circRNAs was identified by receiver operating characteristic (ROC) curve analysis. Results: hsa_circ_0064357 and hsa_circ_0064358 were identified to be lowly expressed, while RAF1 was upregulated in OSCC and OLP tissues more than adjacent normal tissues. Low expression of circRNAs was markedly correlated with TNM stages of OSCC patients. ROC analysis revealed AUC of 0.962 and 0.965 for hsa_circ_0064357 and hsa_circ_0064358, respectively, suggesting that circRNAs can serve as novel diagnostic biomarkers for early detection of OSCC. Conclusion: hsa_circ_0064357 and hsa_circ_0064358 might be involved in the progression and metastasis of OSCC and could be used as promising novel biomarkers for early diagnosis and the clinical monitoring of the malignant transformation of OLP into OSCC.. Keywords: hsa_circ_0064357, hsa_circ_0064358, OSCC, OLP, RAF1 gene |
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