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AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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The STUDIA UNIVERSITATIS BABEŞ-BOLYAI issue article summary The summary of the selected article appears at the bottom of the page. In order to get back to the contents of the issue this article belongs to you have to access the link from the title. In order to see all the articles of the archive which have as author/co-author one of the authors mentioned below, you have to access the link from the author's name. |
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STUDIA PHYSICA - Issue no. 1-2 / 2018 | |||||||
Article: |
A COMPARATIVE STUDY FOR NATURAL DEGRADATION OF THREE LOCAL ANESTHETIC DRUGS FOR HUMAN USE BY 1H NMR RELAXOMETRY AND FT-IR SPECTROSCOPY. Authors: L. R. DRĂGAN, R. CRAINIC, R. FECHETE. |
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Abstract: DOI: 10.24193/subbphys.2018.06 Published Online: 2018-12-20 Published Print: 2018-12-20 pp. 61-73 VIEW PDF FULL PDF Three anesthetics, lidocaine (xylene), ropivacaine and propofol, with localized area of action while used in human surgery, were investigated by 1H NMR relaxometry and ATR-FT-IR spectroscopy. The injectable liquid anesthetics were then subjected to degradation in natural condition during 36 days by exposure to direct sunlight radiation. The sunlight radiation intensity in the infrared and visible domain as well as UV index was monitored using Adafruit SI1145 breakout board sensor. The temperature and humidity was monitored using a digital DHT11 sensor. The evolution of 1H NMR T2-distributions, IR spectra, pH, refraction index, electric conductivity and total dissolved solids (TDS) show a degradation of studied anesthetics but also in some cases a certain recovery. Keywords: ATR-FT-IR spectroscopy, 1H NMR relaxometry, T2-distribution, lidocaine, ropivacaine, propofol. |
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