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AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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The STUDIA UNIVERSITATIS BABEŞ-BOLYAI issue article summary The summary of the selected article appears at the bottom of the page. In order to get back to the contents of the issue this article belongs to you have to access the link from the title. In order to see all the articles of the archive which have as author/co-author one of the authors mentioned below, you have to access the link from the author's name. |
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STUDIA BIOLOGIA - Issue no. 2 / 2012 | |||||||
Article: |
AN ESTIMATION FOR LOWER BOUND OF p53 IN DNA HEALING PROCESS; A MATHEMATICAL APPROACH. Authors: ZEINAB TANOURI, OMID RABIEIMOTLAGH. |
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Abstract: The main goal here is to estimate a lower bound for the level of the p53 protein which is necessary for the DNA damage is repaired by a coeffective work of activated p53 and ATM-p. We consider a system of ODEs as the mathematical model of interactions between the proteins p53, Mdm2, and ATM-p. The model is biologically motivated and can simulate effects of proteins on the DNA damage suppression. It is shown that positive amounts of ATM-p may force the system to pass through a saddle node bifurcation which in turn indicates the lower bound for p53. We see that if the amount of p53 is less that the lower bound then the DNA damage is not suppressed. Finally we use the bifurcation equation and show that how the Hill coefficient of p53 must be controlled in order to optimize the healing process. Keywords: p53-Mdm2 oscillatory model, ATM-p protein, Saddle node bifurcation, Center Manifold, Hill constant. |
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