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    STUDIA PHYSICA - Issue no. 2 / 2002  
         
  Article:   ESR STUDY OF SOME IRRADIATED CYTOSTATIC DRUGS.

Authors:  GHEORGHE DAMIAN.
 
       
         
  Abstract:  Two cytostatic drugs, Mercaptopurine and Azathioprine, have been investigated by ESR spectroscopy in order to detect if they contain or can easily form stable paramagnetic species following sterilization by ionizing radiation. The absorbed dose of drugs was15 kGy corresponding to an average dose used in the sterilization process ESR measurements proved that both of them contained various stable paramagnetic species after irradiation. The Azathioprine drug exhibited very weak ESR signals before irradiation, having hyperfine splitting constant of 15 G and centered around a spectroscopic factor g0.=2.007. Some spectroscopic properties and suggestions concerning possible structure of the radicals are discussed in this paper.  
         
     
         
         
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