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The STUDIA UNIVERSITATIS BABEŞ-BOLYAI issue article summary
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Abstract: Background. The study of the effects of flavonoids on aerobic exercise capacity has evidenced their favorable influence, attributed to their in vivo ergotropic, anti-fatigue and antioxidative action. Aims. To study the influence of the administration of flavonoids on the oxidant/antioxidant (O/AO) balance in rats subjected to physical exercise of various intensities. Methods. The researches were performed in 6 groups of rats (n=10 animals/group): 2 groups of sedentary controls (group 1) and exercise trained rats (group 2) and 4 groups exercise trained for 21 days and supplemented with flavonoids, without loading (group 3), with 5% loading (group 4), with 10% loading (group 5), and with 15% loading (group 6), in which the indicators .of the O/AO balance (malondialdehyde – MDA, protein carbonyls – PC, hydrogen donor capacity – HD, and total sulfhydryl groups – SH) were measured in the serum at moments T1 – day 1 and T21 – day 21. The running treadmill test was performed. Results. The rats supplemented with flavonoids and exercise trained for 21 days have a significant MDA decrease compared to initial values and to the values of all the other groups subjected to physical exercise and supplemented with flavonoids; a significant PC increase compared to initial values; a significant HD decrease compared to initial values; a significant increase in SH groups compared to initial values. The rats supplemented with flavonoids and exercise trained with loading have at 21 days a significant MDA decrease compared to initial values – groups IV and V; a significant PC increase compared to initial values – groups IV, V and VI, and a significant PC increase compared to the values of all the other exercise trained groups supplemented with flavonoids – group IV; a significant HD decrease compared to initial values – group IV, and insignificant differences in HD changes between the groups at 21 days; a significant SH increase compared to initial values and to the values of all the other groups – groups V and VI. Conclusions. Flavonoids have in vivo AO effects, determining a HD and SH increase in sedentary rats and a SH increase in rats subjected to physical exercise of various intensities. Key words: flavonoids, physical exercise, oxidative stress, antioxidants.
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