The STUDIA UNIVERSITATIS BABEŞ-BOLYAI issue article summary

The summary of the selected article appears at the bottom of the page. In order to get back to the contents of the issue this article belongs to you have to access the link from the title. In order to see all the articles of the archive which have as author/co-author one of the authors mentioned below, you have to access the link from the author's name.

 
       
         
    STUDIA CHEMIA - Issue no. 4 / 2016  
         
  Article:   LIPASE CATALYZED PARALLEL KINETIC RESOLUTION OF IBUPROFEN .

Authors:  LÁSZLÓ CSABA BENCZE.
 
       
         
  Abstract:  VIEW PDF: Lipase Catalyzed Parallel Kinetic Resolution of Ibuprofen

A series of commercially available lipases in various solvents using several alcohols as nucleophiles were studied for the stereoselective esterification of ibuprofen and alcoholysis of ibuprofen esters respectively. Novel methods were developed for the stereoselective synthesis of both enantiomers of the target compound. The (S)-selective alcoholysis and (R)-selective hydrolysis in a parallel kinetic resolution procedure in presence of lipase from Mucor miehei as catalyst were performed.

Keywords: lipase, Ibuprofen, enzymatic kinetic resolution, stereoselectivity

Published Online: 2016-12
 
         
     
         
         
      Back to previous page