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    STUDIA CHEMIA - Issue no. 4 / 2014  
         
  Article:   CORRELATION BETWEEN THE ESTIMATED TOTAL THIOSULFINATES CONTENT AND ANTIPLATELET ACTIVITY OF THREE DIFFERENT VARIETIES A. CEPA.

Authors:  MARIOARA MOLDOVAN, RADU OPREAN, CORINA IONESCU.
 
       
         
  Abstract:  The present study aims to establish a correlation between the estimated thiosulfinate compound content of Allium cepa L. (A. cepa) juices and their antiplatelet activity. The juices were obtained from three different varieties of A. cepa, cultivated in three different regions of Romania.The thiosulfinate compound content was estimated using a spectrophotometric method, based on the reaction with 4-mercapto-pyridine (a chromogenic thiol, with a maximum absorbance coefficient at 324 nm). The constant of the reaction kinetic curve was obtained by overlapping experimental data with an exponential function of first degree.The antiplatelet activity of the mentioned juices was measured by using in vitro tests with platelet rich plasma (PRP) obtained from blood collected from healthy human people, with arachidonic acid as platelet agonist.A statistically significant direct proportionality between the estimated thiosulfinate compound content and the antiplatelet activity of the tested A.cepa juices was established.

Keywords: Allium cepa; natural products; platelet; antiplatelet; thiosulfinate compounds.
 
         
     
         
         
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