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Self-assemblies of type I collagen (COL) from bovine Achilles tendon and an anti-cancer drug, such as 5-fluorouracil (FLU) or doxorubicin (DOX), on mica substrate are investigated by atomic force microscopy (AFM). The AFM technique allows visualisation of these assemblies and determination of their morphology and surface roughness. The AFM images show different morphology of self assemblies made of COL, COL-FLU and COL-DOX. The data suggest that the anti-cancer drugs guide to the formation of collagen self assemblies with a notable level of stability, reflecting a high level of nanometer scale order within the adsorbed layers on mica surface. These systems might be well appropriate as biological surfaces for biomedical, drug delivery and sensing applications.

Keywords: collagen, fluorouracil, doxorubicin, mica surface, self-assemblies, morphology, atomic force microscopy