AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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Authors: DAU B. THIN, TRUONG T. V. HOA, BUI B. THINH.
DOI: 10.24193/subbchem.2024.3.06
Published Online: 2024-09-30
Published Print: 2024-09-30
pp. 93-107
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Knema elegans Warb. is an evergreen tree belonging to the Myristicaceae family, primarily native to Southeast Asia. This study examined the chemical composition and assessed the antioxidant and anti-acetylcholinesterase properties of the essential oil from the leaves of K. elegans in Vietnam. Gas chromatography/mass spectrometry analysis revealed the main compounds in the essential oil, including bicyclogermacrene (23.8%), germacrene D (17.1%), β-caryophyllene (15.4%), δ-cadinene (8.2%), and α-cadinol (7.9%). Antioxidant activity was assessed using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2''-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) methods, with half-maximum inhibitory concentration (IC50) values of 93.11 ± 1.95 µg/mL and 114.95 ± 2.41 µg/mL, respectively, indicating moderate antioxidant potential. Additionally, the essential oil exhibited significant anti-acetylcholinesterase effects, with an IC50 value of 87.44 ± 2.52 µg/mL. These findings highlight the biological significance of K. elegans essential oil and suggest avenues for further investigation, particularly in elucidating its mechanisms of action in antioxidant and anti-acetylcholinesterase activities. Notably, this research represents the first comprehensive exploration of the chemical composition, antioxidant activity, and acetylcholinesterase inhibition effects of K. elegans essential oil from its leaves.
Keywords: Knema elegans, sesquiterpenes, Myristicaceae, DPPH, ABTS, AChE
