AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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Authors: DAN-ALEXANDRU TĂTARU, MARIA OLINIC, CĂLIN HOMORODEAN, MIHAI-CLAUDIU OBER, FLORIN-LEONTIN LAZĂR, ANDRADA URDĂ-CÎMPEAN, DAN-MIRCEA OLINIC.
DOI: 10.24193/subbchem.2024.3.04
Published Online: 2024-09-30
Published Print: 2024-09-30
pp. 55-65
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Understanding biochemical mechanisms involved in acute myocardial infarction is crucial for future treatments. The current study analyzed the oxidative stress markers in patients with percutaneously treated acute ST-elevation myocardial infarction and correlated the findings to coronary anatomy and Syntax II score (SS-II). Blood samples were obtained before coronary re-perfusion, after one and 24 hours. The following markers of oxidative stress were determined: malondialdehyde (MDA), reduced glutathione to oxidized glutathione ratio (GSH/GSSG) and total antioxidant capacity (TAC). Thirty-seven consecutive patients were included. The patients were divided into groups according to the infarct-related artery: left anterior descending artery (LAD- group) vs non-LAD group, and according to the calculated SS-II, SS-II≤ 34 vs. SS-II>34. MDA concentration and GSH/GSSG ratio showed non-significant differences between LAD vs non-LAD groups at all time frames. Patients with LAD as the infarct-related artery had a significantly lower TAC 24 hours after re-perfusion: 30.22 ± 9.78 % inhibition in the LAD group vs. 35.7 ± 5.78 % inhibition in the non-LAD group, p=0.013. The oxidative stress markers were similar between patients regardless of the SS-II value, and neither the culprit vessel nor the SS-II significantly influenced the dynamics of oxidative stress markers.
Keywords: oxidative stress, myocardial infarction, Syntax Score.
