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    STUDIA CHEMIA - Issue no. 3 / 2011  
         
  Article:   PROTEIN ADHESION TO BIOACTIVE MICROSPHERES INVESTIGATED BY FLUORESCENCE SPECTROSCOPY.

Authors:  EMOKE LASZLOFFI, ADRIANA VULPOI, VIORICA SIMON.
 
       
         
  Abstract:  This study is focussed on protein functionalization of spray dried samples of CaO-SiO2-P2O5 bioactive glass system calcinated at different temperatures. The protein functionalization of the samples surface was achieved in simulated body fluid enriched with bovine serum albumin. Fluorescence quenching of bovine serum albumin is used for a first evaluation of protein adhesion to bioactive glass samples. Differential thermal analysis was used to determine the heat treatment temperatures. Structural changes induced in the silicate network by calcination were evidenced by X-ray diffraction. The results show that the scaled intensity of tryptophan fluorescence signal recorded from protein solution after glass samples incubation depends on samples heat treatment temperature.

Keywords: bioactive glass; surface functionalization; tryptophan fluorescence.
 
         
     
         
         
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