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    STUDIA CHEMIA - Issue no. 2 / 2016  
         
  Article:   INCLUSION COMPOUNDS OF β-CYCLODEXTRIN-PITOFENONE HYDROCHLORIDE. INVESTIGATIONS OF SOLID FORMS.

Authors:  DUMITRU RISTOIU, IOAN BRATU. 		 
       
         
  Abstract:   Pitofenone hydrochloride (PF.HCl) is a pharmaceutical substance used as an antispasmodic drug. The inclusion compounds of β cyclodexdrin (β-CD) with pitofenone hydrochloride (PF.HCl) have been prepared by co precipitation and freeze-drying methods in order to increase the capacity user acceptance to wafer interest in terms of their taste. For physical chemical characterization the inclusion compounds were analyzed by powder X-ray diffraction, FTIR and ss-NMR spectroscopy, DSC, SEM and the structural architecture of the inclusion compound was proposed by molecular modeling techniques. The new product obtained can be used in the pharmaceutical industry because it provides improved smell and taste as compared to the starting substance. 

Keywords: pitofenone hydrochloride, β-cyclodextrin, SEM, DSC, magnetic and FTIR spectroscopy, molecular modeling
 
         
     
         
         
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