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    STUDIA CHEMIA - Issue no. 2 / 2014  
         
  Article:   EFFECTS OF ALUMINOSILICATES ON LIPID PEROXIDATION AND ANTIOXIDANTS IN AFLATOXIN B1-INDUCED TISSUE INJURY IN CHICKENS.

Authors:  .
 
       
         
  Abstract:   Aflatoxins in poultry cause biochemical changes in major organs, which can assist in the diagnosis of toxication. Producers and researchers have attempted to develop an effective decontamination technology to deal with this feed-borne toxin. Aluminosilicates(clays and zeolites) were preferred because of their high binding capacitiyforaflatoxins and their reducing effect on aflatoxin-absorption from the gastrointestinal tract. The purpose of the present study was to evaluate the toxic effects of aflatoxin B1 (AFB1) by biochemical examination of liver, kidney, spleen, erithrocytes, and pancreas of broiler chickens, and to determine the possible preventive role of ATN-dietary aluminosilicates (mixture of clinoptilolite and bentonite) on the investigated values. In total, 84 broiler chicks were divided into two treatment groups: control-basal diet and basal diet plus 5 g aluminosilicate/kg diet. After 21 days, twelve hours prior to sacrifice, 21 chicks from each group received one dose of AFB1 orally. Lipid peroxidation was significantly increased in the liver and kidney suggesting oxidative stress in these organs. Supplementation with ATN decreased these negative effects. No effects due to AFB1 were observed in enzyme activity and lipid peroxidation inthe pancreas, spleen or red blood cells. This data suggest that a single dose of AFB1 could provide a toxin alleviating effect on biochemical indices of liver and kidney in broiler chicken. Therefore, ATN protects broiler chickens against the harmful effects of AFB1.

Keywords: aflatoxin B1, antioxidative enzymes, clay, kidney, liver, zeolite
 
         
     
         
         
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