AMBIENTUM BIOETHICA BIOLOGIA CHEMIA DIGITALIA DRAMATICA EDUCATIO ARTIS GYMNAST. ENGINEERING EPHEMERIDES EUROPAEA GEOGRAPHIA GEOLOGIA HISTORIA HISTORIA ARTIUM INFORMATICA IURISPRUDENTIA MATHEMATICA MUSICA NEGOTIA OECONOMICA PHILOLOGIA PHILOSOPHIA PHYSICA POLITICA PSYCHOLOGIA-PAEDAGOGIA SOCIOLOGIA THEOLOGIA CATHOLICA THEOLOGIA CATHOLICA LATIN THEOLOGIA GR.-CATH. VARAD THEOLOGIA ORTHODOXA THEOLOGIA REF. TRANSYLVAN
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Authors: ANDREEA BODOKI, GLORIA ALZUET-PIÑA, JOAQUÍN BORRÁS, TAMARA TOPALĂ, ADRIANA HANGAN, GHEORGHE BORODI, LUMINIŢA OPREAN.
DOI: 10.24193/subbchem.2020.1.05
Published Online: 2020-03-30
Published Print: 2020-03-30
pp. 55-69
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Binary Cu(II) complexes of two new N-substituted sulfonamides, N-(pyridin-2-yl-methyl)biphenyl-4-sulfonamide (HL1) and N-bis-(pyridin-2-yl-methyl)biphenyl-4-4’-sulfonamide (H2L2), have been synthesized and characterized by X-ray diffraction, spectroscopic and electrochemical techniques. The structure of complex [Cu(L1)2] consists of a discrete monomeric Cu(II) species stabilized by π-π stacking interactions involving the pyridyl and phenyl rings of the coordinated ligands. In contrast, in the case of complex [Cu(L2)]n, each symmetrical sulfonamide structure coordinates two Cu(II) ions, giving rise to a polymeric chain. Upon coordination, CuN4 chromophores with the N-pyrydil atoms in trans position are generated, and the coordination geometry of both complexes can be best described as highly distorted square-planar. The ability of complex [Cu(L1)2] to promote DNA cleavage with ascorbate activation was also evaluated; the complex has a moderate nuclease activity, being able to partially cleave supercoiled DNA to nicked circular and linear DNA. We herein also report the evaluation of the nuclease activity of complex Cu2(N-(pyridin-2-yl)biphenyl-4-sulfonamidate)4, previously characterized in terms of structure by our group.
Keywords: Cu(II) complexes, N-substituted sulfonamides, X-ray diffraction, nuclease activity.
