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    STUDIA CHEMIA - Issue no. 1 / 2014  
         
  Article:   NEW SOLID FORM OF PROMETHAZINE HYDROCHLORIDE.

Authors:  . 		 
       
         
  Abstract:   The main objective of the present paper was to obtain new solid forms of Promethazine Hydrochloride (PTZ). The preparation was performed by grinding in a ball mill equipment Promethazine Hydrochloride and acetic acid (1:1). To evidence this new solid form of Promethazine Hydrochloride, different investigation techniques have been used: X-ray diffraction (XRD), Fourier transformed infrared (FTIR) spectroscopy, and Differential Thermal Analysis (DTA). XRPD data allowed the determination of the crystallographic system and lattice parameters. The new solid form crystallizes in a monoclinic system having the following unit cell parameters: a=14.52Å, b=9.33Å, c=14.21Å, α=90°, β=110.59°, γ=90°. In the FTIR spectra of PTZ and PTZ-acetic acid the displacement of the bands, indicating the formation of a new compound, appears in the 1500-4000 cm-1 spectral range. In the DTA thermograms, the difference between the onset temperatures suggests that these two samples represent different solid forms.

Keywords: Promethazine Hydrochloride, solid form.
 
         
     
         
         
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