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    STUDIA CHEMIA - Issue no. 1 / 2006  
         
  Article:   THE INHIBITORY EFFECT OF THE ATENOLOL UPON THE ENZYME CATALYZED HYDROGEN PEROXIDE DECOMPOSITION.

Authors:  FLORINA POGACEAN, IOAN BÂLDEA, FLORIN TURBAT.
 
       
         
  Abstract:  The reaction of decomposition of hydrogen peroxide in the presence of catalase has been investigated by means of a Clark oxygen sensor, in the presence and absence of various concentrations of Atenolol a -blocker drug - having an inhibiting role. The Michaelis Menten kinetic parameters have been determined from Lineweaver-Burk plots. The inhibition pattern we have deduced, suggested by the Lineweaver - Burk plots, corresponds to a fully mixed inhibition mechanism. Inhibition constants KI and KI were determined. A kinetic method for the determination of Atenolol has been suggested.  
         
     
         
         
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