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    STUDIA CHEMIA - Issue no. 1 / 2005  
         
  Article:   KINETIC STUDY ON OMEPRAZOLE ACID REACTION AT DIFFERENT PH VALUES BY USING HPLC.

Authors:  L. VLASE, I. BALDEA, SORIN E. LEUCUŢA, L. RUS, LUCIAN COPOLOVICI.
 
       
         
  Abstract:  High performance liquid chromatography (HPLC) has been used to monitor the time evolution of omeprazole under various pH conditions. First-order rate constants for the transformation into sulfenamide, the active inhibitor of the gastric secretion, were determined at 250C. They depend strongly on the acidity of the medium. From this dependence, the first pKa value of omeprazole was calculated, based on kinetic measurements. The acid-catalysed rate constant has been deduced.  
         
     
         
         
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