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Authors: ERIKA KIS, KINGA ZÓR.
Synthetic glucocorticoids are widely used as antiinflammatory and antiallergic drugs. Since drugs contaning glucocorticoid are effectively absorbed, a prolonged glucocorticoid treatment leads to a surplus of endogen glucocorticoids. Long-term glucocorticoid treatments disrupt the endocrine system of the body causing hormonal and metabolic side effects. For this reason, it is necessary to specify the endocrino-metabolic effects of these drugs. Starting from the above findings and from the important physiological roles of glucocorticoids, we investigated the reactions of some endocrine glands after adrenaline-stress and fluocinolone treatment. For this purpose, it was important to compare the effects of high glucocorticoid level produced by stressors with the effects of high glucocorticoid level which occur during dermocorticoid treatment. In the present study adrenaline treatment was the source of glucocorticoid excess on the one hand, and fluocinolone on the other. In both cases, significant physiological changes were observed, the most sensitive gland in changes of glucocorticoid levels being the adrenal gland. Adrenaline stress caused atrophy of the cortical zone of adrenal gland. The fluocinolone-treatment determined hypertrophy of the cortical zone of the adrenal gland. In both cases we observed significant weight changes for the whole body and for each gland.
Keywords: adrenalin, adrenals, glucocorticoids, pancreas, thymus.
