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Authors: YELYZAVETA ZABENKO, TATYANA PIVNEVA.
Mild traumatic brain injury (TBI), often identified with concussion, is not considered to be life threatening in close perspective. However, the information about its delayed neurodegenerative effects is becoming more common. Especially this relates to repeated cases of concussion in military service members and athletes. The aim of our study was to show behavioral and histological changes in a mouse model of repetitive mild traumatic brain injury (rmTBI). No macroscopic brain abnormalities such as skull fractures or intracranial bleeding were found in mice after rmTBI. To detect behavioral alterations, we carried out the “Open field” test on day 5, 10 and 30 since the first impact of five. The behavioral data revealed decrease of motor activity and increase of anxiety level when compared to controls. Immunohistochemical data provided strong evidence of astro- and microgliosis that persisted for weeks after rmTBI. Our results indicate that new mouse model of human rmTBI can be useful in development of neuroprotective approaches for treatment of rmTBI consequences.
Keywords:. hippocampus, immunohistochemistry, mouse model, “Open field” behavioral test, repetitive mild traumatic brain injury.
